![]() ![]() The other half got the placebo first, then the washout, and then high-dose thiamine. Half of the individuals were randomly assigned to received high-dose thiamine for four weeks, followed by a four-week washout period and then four weeks of placebo. The randomized control study found a significant decrease in fatigue in those taking the high-dose B-1.īetween November 2018 and October 2019, Palle Bager and colleagues in Aarhus, Denmark enrolled 40 individuals (35 female, 5 male) with quiescent IBD and fatigue lasting six months or more in a randomized, double-blind placebo-controlled crossover trial. If the survey results suggest that at least some people with ME-CFS, Fibromyalgia or EDS might benefit, I hope to use the results to encourage researchers to conduct a more rigorous study of its potential benefits for individuals with these conditions. I conclude by asking those of you who have tried high-dose thiamine to complete a survey to help the field better understand whether and for whom high-dose thiamine might be helpful. In this guest post for Health Rising, I describe the results of this new study, explore potential explanations for why high-dose thiamine might relieve fatigue, and describe why I think some people with ME/CFS, Fibromyalgia, and the neurological complications of Ehlers-Danlos Syndrome (EDS) might benefit from it. ![]() This randomized trial confirmed the results of one of the earlier Italian studies, finding significant reductions in self-reported fatigue from high-dose oral thiamine hydrochloride over a four-week period among patients with quiescent (i.e., non-active) IBD and long-term fatigue. With the publication in November 2020 of a randomized controlled trial of high-dose thiamine by Palle Bager and colleagues at the Aarhus University Hospital in Denmark, that criticism has largely been addressed. Without the rigor of a randomized controlled trial, it was impossible to know for sure if the benefits were due to thiamine, the placebo effect, or some other explanation. These studies were all fairly small, and none compared the results against a control group of individuals who did not receive the treatment. The fibromyalgia study was one of a series of case studies published by the Italian physician, Antonio Costantini, and colleagues in 2013-2018, finding reductions in fatigue from high-dose thiamine among individuals with a range or neurological and inflammatory conditions, including Inflammatory Bowel Disease (IBD), Multiple Sclerosis, Parkinson’s Disease, and chronic cluster headaches. This is the first clue that the study may involve something other than simple supplementation to remedy a vitamin deficiency. By contrast, the 2013 study on fibromyalgia used 600 to 1,800 mg of thiamine daily, more than 500 times this amount. The recommended daily allowance of thiamine is 1.1-1.2 mg/day. Thiamine deficiency is a serious health problem, but most people in the western world get all the thiamine they need through a healthy diet. A thiamine derivative, thiamine pyrophosphate, is necessary for the citric acid cycle to function properly and produce an adequate amount of the ATP molecules that the body uses for energy. Thiamine, also known as Vitamin B-1, is an essential nutrient that plays a critical role in aerobic cellular respiration. Thiamine plays a key role in aerobic energy production.
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